COMPLEMENT FACTOR H-RELATED PROTEINS CFHR2 AND CFHR5 REPRESENT NOVEL LIGANDS FOR THE INFECTION-ASSOCIATED CRASP PROTEINS OF BORRELIA BURGDORFERI.

Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi.

One virulence property of Borrelia burgdorferi is its resistance to innate immunity, in particular to complement-mediated killing.Serum-resistant B.burgdorferi express up to five distinct complement regulator-acquiring surface proteins (CRASP) which interact with complement regulator factor H (CFH) and factor H-like protein 1 (FHL1) or factor H-rel

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